Histone deacetylases (HDACs) inhibitors

Patent Number: 9387209

Patent Date: 2016-07-12

Patent type: utility

Histone deacetylases inhibitors (HDACIs) and compositions comprising the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit are also disclosed. In one aspect, the invention relates to a compound having the structure or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof. In one embodiment of the invention, Ris ethyl; Ris 2-phenylethyl; Ris hydrogen; Ris fluoro; Ris (2E)-3-N-hydroxyamino-3-oxo-propenyl; and Ris hydrogen, or a salt thereof. In another embodiment of the invention, Ris ethyl; Ris 2-phenylethyl; Ris hydrogen; Ris (2E)-3-N-hydroxyamino-3-oxo-propenyl; Ris chloro or fluoro; and Ris hydrogen, or a salt thereof.

Inventors

First Name Last Name City State Country
Ji-Wang Chern - - -
Pei-Teh Chang - - -
Chao-Wu Yu - - -

IPCs

Section Class Sub Class Group Sub Group
A 61 K 31 517
C 07 D 239 91
C 07 D 403 06

Assignee

Organization First Name Last Name City State Country
ANNJI PHARMACEUTICAL CO., LTD. - - - - -