SUBSTRATES

Brand Owner Address Description
CRYOPLATE Organ Recovery Systems, Inc. 2570 East Devon Avenue Des Plaines IL 60018 Substrates, namely, media prepared with cryo-preserved cells that can be rewarmed for chemical testing in medical research and diagnostic assay systems;
 

Where the owner name is not linked, that owner no longer owns the brand

    
Technical Examples
  1. Provided are methods of identifying inhibitors of ?-secretase that employ modified ?-secretase substrates. The modified ?-secretase substrates have ?-secretase cleavage sites that are altered from wild type. The amino acid sequences of the altered ?-secretase cleavage sites contain different amino acids in at least one of the positions P2-P1-P1'-P2' of the ?-secretase cleavage site. Many of the modified ?-secretase substrates are more efficient substrates for ?-secretase than are corresponding substrates having wild-type sequences, that is, these modified substrates are more susceptible to enzymatic breakdown by ?-secretase. Recombinant polynucleotide molecules encoding the modified ?-secretase substrates are provided. Antibodies that recognize cleavage products of the modified ?-secretase substrates are provided. Stable cell lines expressing the modified ?-secretase substrates are provided. Transgenic animals expressing the modified ?-secretase substrates are provided.