A syringe interface for attaching syringes to a drive mechanism which includes a drive member to impart motion to a syringe plunger includes a plurality of syringe mount apertures having different dimensions to attach each of a plurality of syringes to the syringe interface. Each of the syringes for attachment to the syringe interface includes at least one mounting flange, and each of the plurality of syringes has a different mounting flange dimension. Each of the plurality of syringe mount apertures is in general alignment with an axis of the drive member. A syringe drive mechanism includes a syringe interface as described above. The syringe drive mechanism can further include a sensing system to sense which size of the plurality of syringes is mounted on the syringe interface. The syringe drive mechanism can also include a processor and a memory which are in operative communication with the drive member. The memory includes a control program stored therein. The processor is in communication with the sensing system so that the control program controls the drive member according to the syringe sensed to be attached to the syringe interface. A powered injector includes a drive member and a drive to deliver power to the drive member. A processor of the powered injector is in communication with the drive and with a memory in which at least one control program is stored. The control program includes instructions for control of the drive. The powered injector further includes a syringe interface as described above for attaching syringes to the powered injector so that the drive member can impart motion to a plunger slidably positioned within each of the syringes. The powered injector further includes a sensing system to detect which of the syringes is attached to the syringe interface. The sensing system is in communication with the processor so that the control program controls the drive in a manner determined by the syringe detected to be attached to the syringe interface.