RECREATIONAL ACTIVITIES NATURE

Brand	Owner (click to sort)	Address	Description
CENTIGRADE DRIVES	Centigrade Inc.	6501 Sims Drive Sterling Heights MI 48313	Recreational activities in the nature of conducting guided driving tours;DRIVES;
CENTIGRADE DRIVES	Centigrade Inc.	6501 Sims Drive Sterling Heights MI 48313	Recreational activities in the nature of conducting guided driving tours;The mark consists of a winding road and a setting sun above the words CENTIGRADE DRIVES.;DRIVES;
	Where the owner name is not linked, that owner no longer owns the brand

Technical Examples

Fc fusion proteins of human G-CSF with increased biological activities relative to rhG-CSF on a molar basis are disclosed. The hG-CSF-L-vFc fusion protein comprises hG-CSF, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such hG-CSF-L-vFc fusion proteins exhibit extended serum half-life and increased biological activities, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time.