Alginate biomaterials for the treatment of hepatic disorders

Patent Number: 9387222

Patent Date: 2016-07-12

Patent type: utility

The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.

Inventors

First Name Last Name City State Country
Smadar Cohen - - -
Yaron Ilan - - -
Gadi Lalazar - - -
Eyal Shteyer - - -
Ami Ben-Yaakov - - -
Tsiona Elkayam - - -

IPCs

Section Class Sub Class Group Sub Group
A 61 K 9 00
A 61 K 9 10
A 61 K 38 02
A 61 P 1 16
A 61 K 31 734
A 61 K 31 738
A 61 L 27 20
A 61 L 31 04

Assignee

Organization First Name Last Name City State Country
Ben-Gurion University of the Negev Research and Development Authority - - - - -
Hadasit Medical Research Services and Development Ltd. - - - - -